Selected publications

  1. Cermakova K, Tao L, Dejmek M, Sala M, Montierth MD, Chan YS, Patel I, Chambers C, Loeza Cabrera M, Hoffman D, Parchem RJ, Wang W, Nencka R, Barbieri E, Hodges HC. Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF. Nucl Acids Res (in press). [Highlighted as Breakthrough Article]
  2. Cermakova K, Hodges HC. Interaction modules that impart specificity to disordered protein. Trends Biochem. Sci. 48, 477–490, (2023). [Selected for cover]
  3. Cermakova K, Veverka V, Hodges HC. The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder. Biochem. Soc. Trans. 51, 125–135, (2023).
  4. Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V. A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science. 374(6571):1113-1121, (2021).
  5. Cermakova K Hodges HC. Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation. Molecules 23(8), (2018).
  6. Sharma S*, Cermakova K*, De Rijck J*, Demeulemeester J, Fábry M, El Ashkar S, Lepsik M, Tesina P, Duchoslav V, Novak P, Hubalek M, Srb P, Christ F, Rezacova P, Hodges HC, Debyser Z, and Veverka V. Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc Natl Acad Sci U S A 115(30): E7053-E7062, (2018).
  7. Cermakova K, Weydert C, Christ F, De Rijck J, Debyser Z. Lessons learned: HIV points the way towards precision treatment of Mixed-Lineage Leukemia. Trends in Pharmacological Sciences 37(8): 660-671, (2016).
  8. Tesina P*, Cermakova K*, Horejsi M, Prochazkova K, Fabry M, Christ F, Demeulemeester J, Debyser Z, De Rijck J, Veverka V, Rezacova P. A conserved interaction motif in LEDGF/p75 binding proteins is mimicked by HIV integrase. Nature Communications 6: 7968, (2015).
  9. Cermakova K, Tesina P, Demeulemeester J, El Ashkar S, Mereau H, Schwaller J, Rezacova P, Veverka V, De Rijck J. Validation and Structural Characterisation of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukaemia. Cancer Research 74(18): 5139-5151, (2014).

Themes

My publications have focused on identification of interaction modules involving disordered protein that influence transcription elongation.

My work couples structural biology with new methods in genomics and live-cell imaging.

I have consistently published my work in high-impact journals, including Science, Nature Communications, PNAS, Cancer Research, and others.


Other publications

  1. Chambers C, Cermakova K, Chan YS, Kurtz K, Wohlan K, Lewis AH, Wang C, Pham A, Dejmek M, Sala M, Loeza Cabrera M, Aguilar R, Nencka R, Lacorazza D, Rau RE, Hodges HC. SWI/SNF blockade disrupts PU.1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia. Cancer Research 83, 983–996 (2023).
  2. Van Belle S, El Ashkar S, Cermakova K, Matthijssens F, Goossens S, Canella A, Hodges HC, Christ F, De Rijck J, Van Vlierberghe P, Veverka V and Debyser Z. Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. Cells 10(1), (2021).
  3. Lux V*, Brouns T*, Cermakova K, Srb P, Fabry M, Horejsi M, Kukacka Z, Novak P, Kugler M, Brynda J, De Rijck J, Christ F, Debyser Z, Veverka V. Molecular mechanism of LEDGF dimerization. Structure 28(12), (2020).
  4. Hodges HC*, Stanton BZ*, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nature Structural and Molecular Biology 25(1):61-72, (2018).
  5. El Ashkar S, De Rijck J, Demeulemeester J, Vets S, Madlala P, Cermakova K, Debyser Z, Gijsbers R. BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements. Mol. Ther. Nucleic Acids 3: e179, (2014).
  6. Mereau H*, De Rijck J*, Cermakova K, Kutz A, Juge S, Demeulemeester J, Gijsbers R, Christ F, Debyser Z, Schwaller J. Impairing MLL-fusion gene mediated transformation by dissecting critical interactions with the lens epithelial-derived growth factor (LEDGF/p75). Leukemia 27(6): 1245-1253 (2013).
  7. Prochazkova K, Cermakova K, Pachl P, Sieglova I, Fabry M, Otwinowski Z and Rezacova P. Structure of the effector-binding domain of the arabinose repressor AraR from Bacillus subtilis. Acta Crystallogr. Sect. D 68: 176-185, (2012).

Collaborative themes

My co-authored papers deeped our understanding of the roles of LEDGF and the ATP-dependent chromatin remodeler SWI/SNF.


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